2380321-51-5
2380321-51-5 structure
- Name: CDK4/6-IN-6
- Chemical Name: CDK4/6-IN-6
- CAS Number: 2380321-51-5
- Molecular Formula: C22H27ClFN5O3
- Molecular Weight: 463.93
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2021-10-30 09:20:08
- Modify Date: 2024-01-07 21:14:02
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CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].
| Name | CDK4/6-IN-6 |
|---|
| Description | CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
Cdk4/cyclin D1:0.6 nM (Ki) cdk6/cyclin D3:13.9 nM (Ki) |
| In Vitro | CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1]. |
| References |
| Molecular Formula | C22H27ClFN5O3 |
|---|---|
| Molecular Weight | 463.93 |