2101737-32-8
2101737-32-8 structure
- Name: VU6000918
- Chemical Name: VU6000918
- CAS Number: 2101737-32-8
- Molecular Formula: C18H17F2N5OS
- Molecular Weight: 389.42
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2021-09-13 23:04:33
- Modify Date: 2024-01-11 11:49:02
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VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC50 of 19 nM for hM4[1].
| Name | VU6000918 |
|---|
| Description | VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC50 of 19 nM for hM4[1]. |
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| Related Catalog | |
| Target |
EC50: 19 nM (hM4)[1]. |
| In Vitro | VU6000918 demonstrates statistically significant AHL reversal (18%) from a low oral dose of 0.03 mg/kg and reaches maximal reversal (74%) from a 3 mg/kg dose, with a resulting in vivo plasma EC50 of 74 nM (0.66 nM unbound) based on terminal concentrations measured in the study animals (1.5 hr post-administration of 17j)[1]. |
| References |
| Molecular Formula | C18H17F2N5OS |
|---|---|
| Molecular Weight | 389.42 |