1432051-63-2
1432051-63-2 structure
- Name: TRPV3 74a
- Chemical Name: TRPV3 antagonist 74a
- CAS Number: 1432051-63-2
- Molecular Formula: C17H17F3N2O2
- Molecular Weight: 338.32
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2021-11-14 21:25:48
- Modify Date: 2024-01-16 07:40:40
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TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].
| Name | TRPV3 antagonist 74a |
|---|
| Description | TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2]. |
|---|---|
| Related Catalog | |
| Target |
TRPV3 |
| In Vitro | TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+ responses[2]. |
| In Vivo | TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly[2]. .TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold[1]. Animal Model: WT mice Dosage: 150 μg Administration: Intradermal injection; 30 minutes Result: The number of scratches decreased significantly. |
| References |
| Molecular Formula | C17H17F3N2O2 |
|---|---|
| Molecular Weight | 338.32 |