Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MSN-50
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: MSN-50
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1592908-75-2

1592908-75-2 structure

1592908-75-2 structure

Name: MSN-50
Chemical Name: MSN-50
CAS Number: 1592908-75-2
Molecular Formula: C₃₆H₃₈BrN₃O₆
Molecular Weight: 688.61
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2021-09-11 21:33:48
Modify Date: 2024-01-13 11:04:31
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2].

Name	MSN-50

Description	MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Neurological Disease
Target	Bax Bak
In Vitro	MSN-50 (0~10 uM) inhibits dye release from liposomes in a concentration-dependent fashion. MSN-50 (0~40 uM) inhibits tBid/Bax-mediated MOMP (mitochondrial outer membrane permeabilization) in a concentration-dependent manner and shows concentration-dependent inhibition of Bak-mediated MOMP. MSN-50 inhibits both Bax and Bak after activation by either cBid or Bim. MSN-50 (5 μM; BMK cells) inhibits apoptosis induced by actinomycin D and staurosporin (STS)[1][2].
References	[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017;24(4):493-506.e5. [2]. Jensen K, et al. Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax. Exp Biol Med (Maywood). 2019;244(8):621-629.

Molecular Formula	C₃₆H₃₈BrN₃O₆
Molecular Weight	688.61

Hazard Codes	Xi