1639210-26-6
1639210-26-6 structure
- Name: Fluoroethylnormemantine
- Chemical Name: Fluoroethylnormemantine
- CAS Number: 1639210-26-6
- Molecular Formula: C12H20FN
- Molecular Weight: 197.29
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2021-09-10 08:00:36
- Modify Date: 2024-01-04 20:08:17
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Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3].
| Name | Fluoroethylnormemantine |
|---|
| Description | Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
NMDA receptor[1] |
| In Vivo | Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ 25-35-induced learning impairments in mice[1]. Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1]. Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2]. Animal Model: Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1] Dosage: 0.1, 0.3, 1, 3, 10 mg/kg Administration: I.p. 30 minutes before the behavioral tests Result: Attenuated Aβ 25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit. |
| References |
| Molecular Formula | C12H20FN |
|---|---|
| Molecular Weight | 197.29 |