873888-67-6
873888-67-6 structure
- Name: Antofloxacin hydrochloride
- Chemical Name: Antofloxacin hydrochloride
- CAS Number: 873888-67-6
- Molecular Formula: C18H22ClFN4O4
- Molecular Weight: 412.84
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2021-09-13 08:17:16
- Modify Date: 2024-04-11 09:10:06
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Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin hydrochloride shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin hydrochloride is a weak, reversible inhibitor of CYP1A2 for the treatment of infections caused by a diverse group of bacterial species[1][2][3].
| Name | Antofloxacin hydrochloride |
|---|
| Description | Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin hydrochloride shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin hydrochloride is a weak, reversible inhibitor of CYP1A2 for the treatment of infections caused by a diverse group of bacterial species[1][2][3]. |
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| Related Catalog | |
| In Vivo | Antofloxacin (2.5~160 mg/kg; s.c.; 24 hours) penetration ratio ranges from 1.22 to 1.54 for the total drug concentrations and is independent of the dose levels[3].Antofloxacin increases the plasma theophylline concentration, partly by acting as a mechanism based inhibitor of CYP1A2. Antofloxacin inhibits the formation of the three metabolites of theophylline was time-, concentration- and NADPH-dependent, which is characteristic of mechanism-based inhibition[2]. Animal Model: Mice (Pharmacokinetic Analysis)[3] Dosage: 2.5~160 mg/kg Administration: S.c.; 24 hours Result: Penetration ratio ranged from 1.22 to 1.54 for the total drug concentrations and was independent of the dose levels. |
| References |
| Molecular Formula | C18H22ClFN4O4 |
|---|---|
| Molecular Weight | 412.84 |