1414808-96-0
1414808-96-0 structure
- Name: Tryptamine guanosine carbamate
- Chemical Name: Tryptamine guanosine carbamate
- CAS Number: 1414808-96-0
- Molecular Formula: C21H23N7O6
- Molecular Weight: 469.45
- Catalog: Research Areas Neurological Disease
- Create Date: 2021-09-30 17:18:28
- Modify Date: 2024-01-12 16:26:49
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Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance[1].
| Name | Tryptamine guanosine carbamate |
|---|
| Description | Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance[1]. |
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| Related Catalog | |
| In Vivo | Pretreatment with 20 nmol TpGc enhanced morphine antinociception in 129 HINT1+/+ mice and is devoid of effect in HINT1-/- mice.The administration of 7 and 20 nmol of TpGc 20min before the morphine priming dose significantly reduces the development of acute antinociceptive tolerance in HINT1+/+ mice but not in HINT1-/- animals[1]. TpGc reduces the recruitment of NMDAR activity promoted by morphine. In mice suffering from chronic constriction injury concurrent with increased NMDAR activity, a single intracerebroventricular administration of TpGc (20 nmol) attenuates NMDAR function and alleviated mechanical allodynia for several days[1]. |
| References |
| Molecular Formula | C21H23N7O6 |
|---|---|
| Molecular Weight | 469.45 |