2130996-00-6
2130996-00-6 structure
- Name: GLPG2938
- Chemical Name: GLPG2938
- CAS Number: 2130996-00-6
- Molecular Formula: C20H19F6N7O2
- Molecular Weight: 503.4
- Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
- Create Date: 2021-09-14 14:03:45
- Modify Date: 2024-01-15 17:15:07
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GLPG2938 is a potent and selective S1P2 antagonist. GLPG2938 can be used for the research of idiopathic pulmonary fibrosis[1].
| Name | GLPG2938 |
|---|
| Description | GLPG2938 is a potent and selective S1P2 antagonist. GLPG2938 can be used for the research of idiopathic pulmonary fibrosis[1]. |
|---|---|
| Related Catalog | |
| Target |
S1PR2 |
| In Vitro | GLPG2938 (0.5~5 μM; HPF cells) significantly prevents the S1P-mediated contraction at all tested concentrations[1]. |
| In Vivo | GLPG2938 (1~10 mg/kg; p.o.) displays a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score[1]. GLPG2938 shows good pharmacokinetics, with long half-life, low clearance, and good bioavailability in all species, especially in dogs[1]. Animal Model: Male C57BL/6 mice[1] Dosage: 1~10 mg/kg Administration: P.o. Result: Displayed a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score. |
| References |
| Molecular Formula | C20H19F6N7O2 |
|---|---|
| Molecular Weight | 503.4 |