Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dicarbine
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Purity: 98.0%
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17411-19-7

17411-19-7 structure

Name: Dicarbine
Chemical Name: 2,8-dimethyl-1,3,4,4a,5,9b-hexahydropyrido[4,3-b]indole
CAS Number: 17411-19-7
Molecular Formula: C₁₃H₁₈N₂
Molecular Weight: 202.30
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2016-06-23 03:20:22
Modify Date: 2024-02-02 11:08:41
Dicarbine blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used to treat patients with schizophrenia and alcoholic psychosis in clinical[1][2].

Name	2,8-dimethyl-1,3,4,4a,5,9b-hexahydropyrido[4,3-b]indole
Synonyms	Carbidine Dicarbine

Description	Dicarbine blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used to treat patients with schizophrenia and alcoholic psychosis in clinical[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine receptor[1][2].
References	[1]. Barkov NK, et al. [Effect of carbidine on conditioned defense reflexes]. Biull Eksp Biol Med. 1975 Apr;79(4):61-4. [2]. DICARBINE

Density	1.043g/cm3
Boiling Point	305.7ºC at 760mmHg
Molecular Formula	C₁₃H₁₈N₂
Molecular Weight	202.30
Flash Point	128.8ºC
Exact Mass	202.14700
PSA	15.27000
LogP	2.28410
Vapour Pressure	0.000806mmHg at 25°C
Index of Refraction	1.554

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU9990175

CHEMICAL NAME :: 1H-Pyrido(4,3-b)indole, 2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-

CAS REGISTRY NUMBER :: 17411-19-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H18-N2

MOLECULAR WEIGHT :: 202.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 357 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 153 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 237 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

HS Code	2933990090

19686-05-6

17411-19-7

Literature: Kucherova, N. F.; Sipilina, N. M.; Novikova, N. N.; Silenko, I. D.; Rozenberg, S. G.; Zagorevskii, V. A. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , p. 1051 - 1053 Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 10 p. 1383 - 1386

Precursor 1
19686-05-6
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%