89196-95-2

89196-95-2 structure

Name: 2-BFI hydrochloride
Chemical Name: 2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole,hydrochloride
CAS Number: 89196-95-2
Molecular Formula: C₁₁H₁₁ClN₂O
Molecular Weight: 222.67
Catalog: Signaling Pathways GPCR/G Protein Imidazoline Receptor
Create Date: 2018-12-23 19:18:15
Modify Date: 2024-01-30 22:32:54
RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI)[1][2].

Name	2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole,hydrochloride
Synonyms	2-BFI hydrochloride

Description	RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI)[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Ki: 70.1 nM (imidazoline I2 receptor)[1]
In Vivo	RX 801077 hydrochloride (5、10、20 mg/kg；腹腔注射；每天两次，持续 3 天) 在创伤性脑损伤大鼠模型中抑制 NLRP3 炎性体诱导的炎症和坏死性凋亡[2]。 Animal Model: 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] Dosage: 5, 10, 20 mg/kg Administration: I.p.; twice daily for 3 days Result: Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
References	[1]. Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. [2]. Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.

Boiling Point	348.1ºC at 760 mmHg
Molecular Formula	C₁₁H₁₁ClN₂O
Molecular Weight	222.67
Flash Point	164.4ºC
Exact Mass	222.05600
PSA	37.53000
LogP	2.34900

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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