Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Deoxy-D-galactose
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Purity: 98.0%
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1949-89-9

1949-89-9 structure

Name: 2-Deoxy-D-lyxo-hexose
Chemical Name: 2-deoxy-D-galactose
CAS Number: 1949-89-9
Molecular Formula: C₆H₁₂O₅
Molecular Weight: 164.156
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-03-08 08:00:00
Modify Date: 2024-01-08 19:55:27
2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1].

Name	2-deoxy-D-galactose
Synonyms	2-DEOXY-D-LYXOHEXOSE 2-deoxy-galactose 2-deoxy-lyxo-hexose 2-Deoxy-B-D-Lyxo-Hexose EINECS 217-765-3 Deoxygalactose 2-Dexoy-D-Lyxohexose D-2-Desoxygalactose D-2-deoxygalactose D-lyxo-Hexose, 2-deoxy- 2-Deoxy-D-GalaCLose D-lyxo-Hexose,2-deoxy lyxo-Hexose, 2-deoxy- 2-Deoxy-D-Galactopyranose 2-Deoxy-D-galactose MFCD00014649 DEOXY-D-GALACTOSE,2 2-deoxy-D-talose (3R,4R,5R)-3,4,5,6-Tetrahydroxyhexanal

Description	2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	2-Deoxy-D-galactose (1 mM/L; 5 h) is rapid phosphorylation during the first 30 min and decreases to approximately 20% of this rate during the subsequent hours in ascites hepatoma cells[4].
In Vivo	2-Deoxy-D-galactose (380 mg/kg; i.p.; for 6 times) strongly decreases contents of UMP, UDPG, and UDP galactose in rat livers[1]. 2-Deoxy-D-galactose (2-8 μM; intracerebroventricularly injection; once) shows PAR impairment 30 min before the acquisition trial a dose of 4 μM and 15 min delay after do-gal administration[3]. Animal Model: Male adult Wistar rats with passive avoidance response (PAR) acquisition trial[3] Dosage: 2, 4 and 8 μM Administration: Intracerebroventricularly injection; 2-8 μM; once Result: Exhibited PAR disruption at a dose of 4 μM.
References	[1]. Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17(2):246-53. [2]. Krug M, et al. The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 1991 Feb 1;540(1-2):237-42. [3]. Lorenzini CG, et al. 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68(3):317-24. [4]. Smith DF, Keppler DO. 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition. Eur J Biochem. 1977 Feb 15;73(1):83-92.

Density	1.4±0.1 g/cm3
Boiling Point	456.7±45.0 °C at 760 mmHg
Melting Point	107-110 °C(lit.)
Molecular Formula	C₆H₁₂O₅
Molecular Weight	164.156
Flash Point	244.1±25.2 °C
Exact Mass	164.068466
PSA	90.15000
LogP	-3.07
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.534

Hazard Codes	Xi: Irritant;
Risk Phrases	20/21/22-36/37/38
Safety Phrases	S24/25
WGK Germany	3
HS Code	2912491000

73991-08-9

~84%

1949-89-9

Literature: Wong, Margaret Y. H.; Gray, Gary R. Carbohydrate Research, 1980 , vol. 80, p. 87 - 98

6207-30-3

1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98

73982-55-5

1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98

73982-54-4

1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98

73982-59-9

1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98

Precursor 5
73991-08-9 6207-30-3 73982-55-5 73982-54-4
73982-59-9
DownStream 1
3573-50-0

HS Code	2912491000
Summary	2912491000. other aldehyde-alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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