73465-43-7

73465-43-7 structure

Name: 1-Deoxymannojirimycin hydrochloride
Chemical Name: (+)-1-Deoxynojirimycin hydrochloride
CAS Number: 73465-43-7
Molecular Formula: C₆H₁₄ClNO₄
Molecular Weight: 199.633
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-21 21:15:26
Modify Date: 2024-01-05 16:07:14
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2].

Name	(+)-1-Deoxynojirimycin hydrochloride
Synonyms	(2R,3R,4R,5R)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidinium chloride Piperidinium, 3,4,5-trihydroxy-2-(hydroxymethyl)-, chloride, (2R,3R,4R,5R)- (1:1) 1-deoxymannojirimycin hydrochloride (2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride (1:1)

Description	1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	IC50: 20 μM (α1,2-mannosidase I)[1] N-linked glycosylation[2] HIV‐1[2]
References	[1]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98. [2]. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	22-24/25-36
RIDADR	NONH for all modes of transport
WGK Germany	3