32744-80-2

32744-80-2 structure

Name: chlorogentisyl alcohol
Chemical Name: chlorogentisyl alcohol
CAS Number: 32744-80-2
Molecular Formula: C₇H₇ClO₃
Molecular Weight: 174.58200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-02-15 06:40:36
Modify Date: 2024-01-03 11:22:06
3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 µM, an Ki value of 0.58 µM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].

Name	chlorogentisyl alcohol
Synonyms	3-Chlorgentisylalkohol 3-Chlorogentisyl alcohol 2,5-Dihydroxy-3-chlorobenzyl alcohol 2-(Hydroxymethyl)-6-chlorohydroquinone 6-Chlorogentisylalcohol 2-Chloro-6-(hydroxymethyl)-1,4-benzenediol 2-chloro-6-(hydroxymethyl)benzene-1,4-diol 3-chloro-2,5-dihydroxy benzyl alcohol AMUDOL

Description	3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 µM, an Ki value of 0.58 µM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.74 µM (β-glucuronidase)[1]
In Vitro	3-Chlorogentisyl alcohol (compound 1) (20 µM; 24 h) shows antiproliferative activity in Namalwa, U266 cells[1]. Cell Proliferation Assay[1] Cell Line: Namalwa, U266 cells Concentration: 20 µM Incubation Time: 24 h Result: Showed antiproliferative activity with the viability rate of 70.40% and 94.08% in Namalwa, U266 cells, respectively.
References	[1]. YichaoGe， et al. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European Journal of Medicinal Chemistry, 2022, 114699.