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33889-69-9

33889-69-9 structure
33889-69-9 structure
  • Name: Silicristin
  • Chemical Name: silychristin
  • CAS Number: 33889-69-9
  • Molecular Formula: C25H22O10
  • Molecular Weight: 482.436
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-06-03 08:00:00
  • Modify Date: 2024-01-02 20:13:29
  • Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].
Name silychristin
Synonyms Silicristin
EINECS 251-720-9
Silicristinum
(2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydrochromen-4-one
Silicristinum [INN-Latin]
Silicristina
(2R,3R)-3,5,7-Trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydro-4H-chromen-4-one
Silicristina [INN-Spanish]
4H-1-Benzopyran-4-one, 2-[(2R,3S)-2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
Silychristin
Silymarin II
Silicristine [INN-French]
(2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-2,3-dihydrobenzofuran-5-yl]chroman-4-one
Silicristine
Description Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].
Related Catalog
References

[1]. Biedermann D, et al. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092.

[2]. Johannes J, et al. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology. 2016 Apr;157(4):1694-701.
Density 1.6±0.1 g/cm3
Boiling Point 782.0±60.0 °C at 760 mmHg
Molecular Formula C25H22O10
Molecular Weight 482.436
Flash Point 270.5±26.4 °C
Exact Mass 482.121307
PSA 166.14000
LogP 2.20
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.716
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
Safety Phrases 22-45
RIDADR NONH for all modes of transport
Precursor  3

DownStream  0


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