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29976-53-2

29976-53-2 structure
29976-53-2 structure
  • Name: N-Carbethoxy-4-piperidone
  • Chemical Name: N-Carbethoxy-4-piperidone
  • CAS Number: 29976-53-2
  • Molecular Formula: C8H13NO3
  • Molecular Weight: 171.194
  • Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
  • Create Date: 2018-09-27 12:33:47
  • Modify Date: 2024-01-02 20:24:40
  • N-Carbethoxy-4-piperidone is a metabolite of Loratadine (HY-17043). Loratadine is a selective inverse peripheral histamine H1-receptor agonist, and shows anti-dengue-virus (DENV) activity[1][2][3].

Name N-Carbethoxy-4-piperidone
Synonyms Ethyl 4-oxo-1-piperidinecarboxylate
N-carboethoxy-4-piperidinone
1-CARBETHOXY-4-PIPERIDONE
4-oxo-piperidine-1-carboxylic acid ethyl ester
EINECS 249-984-5
AURORA KA-3057
MFCD00006188
N-Ethoxycarbonyl-4-piperidinone
1-Ethoxycarbonyl-4-piperidinone
ethyl 4-oxopiperidine-1-carboxylate
N-ETHOXYCARBONYL-4-PIPERIDONE
N-Carbethoxy-4-piperidone
1-Carbethoxy-4-piperidone,1-Ethoxycarbonyl-4-piperidone,Ethyl 4-oxo-1-piperidinecarboxylate
1-(Ethoxycarbonyl)-4-piperidone
carbethoxy-4-piperidone
4-Oxo-1-piperidinecarboxylic acid ethyl ester
N-Carbethoxy-4-piperidon
Ethyl-4-oxopiperidin-1-carboxylat
1-carboethoxy-4-piperidone
1-Ethoxycarbonyl-4-oxopiperidine
Loratadine impurity H
N-CARBOETHOXY-4-PIPERIDONE
1-Piperidinecarboxylic acid, 4-oxo-, ethyl ester
1-Ethoxycarbonyl-4-piperidone
N-Carbithoxy-4-Piperidone
N-Carbethoxypiperidone
Loratadine Impurity 8
Description N-Carbethoxy-4-piperidone is a metabolite of Loratadine (HY-17043). Loratadine is a selective inverse peripheral histamine H1-receptor agonist, and shows anti-dengue-virus (DENV) activity[1][2][3].
In Vitro N-Carbethoxy-4-piperidone (piperidinone 4) shows toxicity to C. dubia, B. calyciflorus and P. subcapitata[1].
Density 1.2±0.1 g/cm3
Boiling Point 273.4±33.0 °C at 760 mmHg
Molecular Formula C8H13NO3
Molecular Weight 171.194
Flash Point 87.8±0.0 °C
Exact Mass 171.089539
PSA 46.61000
LogP -0.31
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.483
Storage condition 2-8°C
Water Solubility slightly soluble
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/38
Safety Phrases S23-S24/25-S37/39-S26
WGK Germany 3
HS Code 2933399090

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29976-53-2 structure

29976-53-2

Literature: SUVEN LIFE SCIENCES LIMITED; Nirogi, Ramakrishna; Mohammed, Abdul Rasheed; Yarlagadda, Suresh; Ravella, Srinivasa Rao; Shinde, Anil Karbhari; Kamphampati, Ramasastri; Roayapalley, Praveen Kumar; Jayarajan, Pradeep; Bhyrapuneni, Gopinadh; Patnala, Sriramachandra Murthy; Ravula, Jyothsna; Jasti, Venkateswarlu Patent: US2014/187581 A1, 2014 ; Location in patent: Paragraph 0195-0198 ;

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Literature: US2005/234046 A1, ; Page/Page column 59 ; US 20050234046 A1

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29976-53-2

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5439 - 5442

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29976-53-2

Literature: Tetrahedron Letters, , vol. 34, # 24 p. 3863 - 3866

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29976-53-2 structure

29976-53-2

Literature: Praliev, K. D.; Belikova, N. A.; Isin, Zh. I.; Sokolov, D. V. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 60 - 61 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 70 - 71

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29976-53-2 structure

29976-53-2

Literature: Tetrahedron Letters, , vol. 34, # 24 p. 3863 - 3866
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%