DC Chemicals Limited
China
Product Name: VAS3947
Price: $700.0/100mg $1200.0/250mg $2400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

869853-70-3

869853-70-3 structure

Name: VAS 3947
Chemical Name: 3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine
CAS Number: 869853-70-3
Molecular Formula: C₁₄H₁₀N₆OS
Molecular Weight: 310.334
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-09-12 17:33:16
Modify Date: 2024-01-12 07:59:50
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins[1][2].

Name	3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine
Synonyms	3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine 3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-(2-oxazolylthio)-3-(phenylmethyl)-

Description	VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease
In Vitro	VAS3947 consistently inhibits NADPH oxidase activity in low micromolar concentrations, and interferes neither with ROS detection nor with XOD or eNOS activities. VAS3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection. In CaCo-2 cell homogenates, VAS3947 completely blocks NADPH-dependent ROS production with an IC50 of 12 µM[1]. VAS3947 triggers cell proliferation arrest and death independently of anti-NOX activity. The IC50 values of the different cell lines ranges from 2.6 ± 0.6 µM for the most sensitive cell line MV-4-11 to 4.9 µM for THP-1, the least sensitive[2]. VAS3947 decreases ROS levels. VAS3947 triggers endoplasmic reticulum (ER) stress and consequent unfolding protein response (UPR)[2]. VAS3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3].
In Vivo	NADPH 氧化酶抑制剂
References	[1]. Wind S, et al. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol. 2010;161(4):885-898. [2]. El Dor M, et al. VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines. Int J Mol Sci. 2020;21(15):5470. Published 2020 Jul 31. [3]. Lu WJ, et al. VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC. Sci Rep. 2019;9(1):18852. Published 2019 Dec 11.

Density	1.6±0.1 g/cm3
Boiling Point	577.8±60.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₀N₆OS
Molecular Weight	310.334
Flash Point	303.3±32.9 °C
Exact Mass	310.063690
LogP	1.96
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.801
Storage condition	2-8°C

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