616885-87-1
616885-87-1 structure
- Name: Memoquin
- Chemical Name: 2,5-Bis({6-[ethyl(2-methoxybenzyl)amino]hexyl}amino)-1,4-benzoquinone
- CAS Number: 616885-87-1
- Molecular Formula: C38H56N4O4
- Molecular Weight: 632.876
- Catalog: Signaling Pathways Neuronal Signaling AChE
- Create Date: 2021-09-09 12:45:14
- Modify Date: 2024-01-13 16:39:58
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Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD)[1][2].
| Name | 2,5-Bis({6-[ethyl(2-methoxybenzyl)amino]hexyl}amino)-1,4-benzoquinone |
|---|---|
| Synonyms |
2,5-Cyclohexadiene-1,4-dione, 2,5-bis[[6-[ethyl[(2-methoxyphenyl)methyl]amino]hexyl]amino]-
2,5-bis({6-[ethyl(2-methoxybenzyl)amino]hexyl}amino)cyclohexa-2,5-diene-1,4-dione 2,5-Bis({6-[ethyl(2-methoxybenzyl)amino]hexyl}amino)-1,4-benzoquinone |
| Description | Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
hAChE:1.55 nM (IC50) BACE1:108 nM (IC50) |
| In Vitro | Memoquin 抑制 hAChE，hAChE 诱导的 Aβ(1-40) 聚集，Aβ(1-42) 自聚集和 BACE-1 的 IC50 值分别为 0.00155，28.3，5.93 和 0.108 μM[2]。 Memoquin 具有与 hAChE 结合的特性，Ki 值为 2.6 nM[2]。 |
| In Vivo | Memoquin (7-15 mg/kg；口服，一次) 可挽救 scopolamine 诱导的遗忘模型的记忆缺陷[1]。 Memoquin (15 mg/kg；口服，每天 1 次，连续 2-6 天) 6 天治疗可完全挽救 Aβ1-42 诱导的遗忘模型的记忆缺陷[1]。 Animal Model: Mice with scopolamine-induced amnesia[1] Dosage: 7, 10 and 15 mg/kg Administration: Oral administration; 7, 10 and 15 mg/kg, once Result: Reversed the scopolamine-induced memory deficits and verified by a T-maze test. Rescueed episodic memory impairment at a dose of 15 mg/kg. Animal Model: Mice with Aβ- induced amnesia[1] Dosage: 15 mg/kg Administration: Oral administration; 15 mg/kg, daily for 2, 4, and 6 days before behavioral testing Result: Weekly alleviated the insult induced by Aβ1-42 for 2-4 days treatment and fully rescued with a 6-day treatment. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 722.9±60.0 °C at 760 mmHg |
| Molecular Formula | C38H56N4O4 |
| Molecular Weight | 632.876 |
| Flash Point | 391.0±32.9 °C |
| Exact Mass | 632.430176 |
| LogP | 7.36 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.572 |