1424635-83-5
1424635-83-5 structure
- Name: Lats-IN-1
- Chemical Name: Lats-IN-1
- CAS Number: 1424635-83-5
- Molecular Formula: C18H14N4OS
- Molecular Weight: 334.39
- Catalog: Research Areas Others
- Create Date: 2021-06-16 13:16:49
- Modify Date: 2024-08-10 00:05:44
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Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].
| Name | Lats-IN-1 |
|---|---|
| Synonyms |
MFCD33402276
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- |
| Description | Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1]. |
|---|---|
| Related Catalog | |
| In Vitro | The IC50 for Lats-IN-1 increases with the ATP concentration[1]. Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM[1]. Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids[1]. Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation[1]. Cell Proliferation Assay[1] Cell Line: MCF 10A cells Concentration: 10 μM Incubation Time: 24 hours Result: Decreased the phosphorylation of Yap at residue S127. |
| References |
| Density | 1.36±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H14N4OS |
| Molecular Weight | 334.39 |
| Hazard Codes | Xi |
|---|