391889-85-3
391889-85-3 structure
- Name: CAY10760
- Chemical Name: CAY10760
- CAS Number: 391889-85-3
- Molecular Formula: C28H24ClN3O3
- Molecular Weight: 485.961
- Catalog: Signaling Pathways Cell Cycle/DNA Damage RAD51
- Create Date: 2021-08-31 08:15:45
- Modify Date: 2025-09-26 19:33:49
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Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination[1].
| Name | CAY10760 |
|---|---|
| Synonyms |
2(1H)-Quinolinone, 6-chloro-3-[4,5-dihydro-5-(4-methoxyphenyl)-1-(1-oxopropyl)-1H-pyrazol-3-yl]-4-phenyl-
CAY10760 6-Chloro-3-[5-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone |
| Description | Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Homologous recombination-IN-1 (10-40 μM; 5 h) reduces cell homologous recombination in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: BxPC3 cells Concentration: 10-40 μM Incubation Time: 5 hours Result: Led to homologous recombination inhibition with an EC50 value of 18.4 μM. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C28H24ClN3O3 |
| Molecular Weight | 485.961 |
| Exact Mass | 485.150604 |
| LogP | 4.39 |
| Index of Refraction | 1.660 |