1695533-44-8

1695533-44-8 structure

Name: Erastin2
Chemical Name: Erastin2
CAS Number: 1695533-44-8
Molecular Formula: C₃₆H₃₅ClN₄O₄
Molecular Weight: 623.141
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2021-05-05 13:16:14
Modify Date: 2024-01-12 10:59:53
Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter[1][2].

Name	Erastin2
Synonyms	Erastin2 4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- 2-({4-[(4-Chlorophenoxy)acetyl]-1-piperazinyl}methyl)-3-(4-isopropoxy-3-biphenylyl)-4(3H)-quinazolinone

Description	Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Apoptosis >> Ferroptosis
References	[1]. Cao JY, et al. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. [2]. Dixon SJ, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014 May 20;3:e02523.