1459161-55-7

1459161-55-7 structure

Name: Sucralose-d6
Chemical Name: Sucralose-d6
CAS Number: 1459161-55-7
Molecular Formula: C₁₂H₁₃D₆Cl₃O₈
Molecular Weight: 403.67
Catalog: Research Areas Cancer
Create Date: 2021-06-24 18:42:08
Modify Date: 2024-01-04 06:13:36
Sucralose-d6 is deuterium labeled Sucralose. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents[1][2].

Name	Sucralose-d6
Synonyms	α-D-Galactopyranoside-C6,C6-d2, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-1,1,6,6-d4 4-chloro-4-deoxy- SUCRALOSE-D6 1,6-Dichloro-1,6-dideoxy-β-D-(1,1,6,6-2H4)fructofuranosyl 4-chloro-4-deoxy-α-D-(C6,C6-2H2)galactopyranoside

Description	Sucralose-d6 is deuterium labeled Sucralose. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents[1][2].
Related Catalog	Research Areas >> Cancer
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17. [3]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250.