1328934-40-2

1328934-40-2 structure

Name: LEE011-D6
Chemical Name: Ribociclib D6
CAS Number: 1328934-40-2
Molecular Formula: C₂₃H₂₄D₆N₈O
Molecular Weight: 440.57
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2020-08-10 15:07:11
Modify Date: 2025-08-25 12:20:33
Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

Name	Ribociclib D6

Description	Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

Molecular Formula	C₂₃H₂₄D₆N₈O
Molecular Weight	440.57