111755-76-1

111755-76-1 structure

Name: Propargylcholine (bromide)
Chemical Name: Propargylcholine (bromide)
CAS Number: 111755-76-1
Molecular Formula: C₇H₁₄BrNO
Molecular Weight: 208.096
Catalog: Research Areas Others
Create Date: 2021-05-28 22:16:28
Modify Date: 2024-01-12 11:51:08
Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells[1][2].

Name	Propargylcholine (bromide)
Synonyms	Propargylcholine (bromide) 2-Propyn-1-aminium, N-(2-hydroxyethyl)-N,N-dimethyl-, bromide (1:1) N-(2-Hydroxyethyl)-N,N-dimethyl-2-propyn-1-aminium bromide

Description	Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Propargylcholine bromide (10, 50 µM; 24 h) 掺入 NIH 3T3细胞中，并以浓度依赖性方式显示强染色 (用 Alexa568 叠氮化物固定并染色)[1]。 Immunofluorescence[1] Cell Line: NIH 3T3 cells Concentration: 10, 50 µM Incubation Time: 24 h Result: Showed strong staining proportional in intensity to the concentration of added Propargylcholine bromide.
In Vivo	Propargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) 在恒河猴中给药后 1 周内有效掺入新合成的髓磷脂并持续存在超过 6 周[2]。
References	[1]. Jao CY, et al. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15332-7. [2]. Karen R. Bottenfield, et al. Optimization of Propargylcholine to Label Newly Synthesized Myelin in the Rhesus Monkey Brain. FASEB J. 2020, 34(S1): 1-1.