866924-39-2
866924-39-2 structure
- Name: GW280264X
- Chemical Name: Carbamic acid
- CAS Number: 866924-39-2
- Molecular Formula: C28H41N5O6S
- Molecular Weight: 575.72
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2021-05-20 23:28:55
- Modify Date: 2024-01-10 09:18:35
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GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2].
| Name | Carbamic acid |
|---|
| Description | GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. |
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| Related Catalog | |
| Target |
ADAM17:8 nM (IC50) ADAM10:11.5 nM (IC50) |
| In Vitro | The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown[2]. Cell Viability Assay[2] Cell Line: Glioblastoma-initiating cells (GIC) GS-7 cells Concentration: 0.1, 1, and 3 µM Incubation Time: 48 hours Result: Proliferation of GIC is inhibited through inhibition of ADAM10 and ADAM17. |
| In Vivo | Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI)[3]. Animal Model: C57BL/6 mice[3] Dosage: 100 µg/kg Administration: I.p. injected; every day for one week starting 4 h post-surgery Result: Showed significantly improved functional recovery compared to the control group. |
| References |
| Density | 1.229±0.06 g/cm3 |
|---|---|
| Molecular Formula | C28H41N5O6S |
| Molecular Weight | 575.72 |