1215654-26-4

1215654-26-4 structure

Name: RS 100329 HCl
Chemical Name: RS 100329 hydrochloride
CAS Number: 1215654-26-4
Molecular Formula: C₂₀H₂₆ClF₃N₄O₃
Molecular Weight: 462.894
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2021-05-02 21:00:09
Modify Date: 2025-08-25 10:49:37
RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2].

Name	RS 100329 hydrochloride
Synonyms	2,4(1H,3H)-Pyrimidinedione, 5-methyl-3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-, hydrochloride (1:1) 5-Methyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl}propyl)-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1) 5-Methyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)pyrimidine-2,4(1H,3H)-dione hydrochloride (1:1)

Description	RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	pKi: 9.6 (α1A-adrenoceptor), 7.9 (α1D-adrenoceptor) and 7.5 (α1B-adrenoceptor)[2]
In Vitro	RS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner[2].
In Vivo	RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions[1]. Animal Model: Sprague Dawley rats (300-390 g)[1] Dosage: 0.01-0.1 mg/kg Administration: Intravenous injection Result: Caused a fall in baseline urethral pressure reaching a maximum of 23%.