2489876-37-9
2489876-37-9 structure
- Name: GMB-475
- Chemical Name: GMB-475
- CAS Number: 2489876-37-9
- Molecular Formula: C43H46F3N7O7S
- Molecular Weight: 861.93
- Create Date: 2021-01-25 21:13:34
- Modify Date: 2024-04-06 12:55:36
-
GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1].
| Name | GMB-475 |
|---|
| Description | GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1]. |
|---|
| Molecular Formula | C43H46F3N7O7S |
|---|---|
| Molecular Weight | 861.93 |