GMB-475
Modify Date: 2024-04-06 12:55:36
GMB-475 structure
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Common Name | GMB-475 | ||
|---|---|---|---|---|
| CAS Number | 2489876-37-9 | Molecular Weight | 861.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C43H46F3N7O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GMB-475GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1]. |
| Name | GMB-475 |
|---|
| Description | GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1]. |
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| Molecular Formula | C43H46F3N7O7S |
|---|---|
| Molecular Weight | 861.93 |