2376255-48-8

2376255-48-8 structure

Name: Ac-FLTD-CMK
Chemical Name: Ac-FLTD-CMK
CAS Number: 2376255-48-8
Molecular Formula: C₂₆H₃₇ClN₄O₈
Molecular Weight: 569.05
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2021-01-06 23:51:01
Modify Date: 2025-08-25 11:31:15
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].

Name	Ac-FLTD-CMK

Description	Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
Target	Caspase-1:46.7 nM (IC50) Caspase-4:1.49 μM (IC50) Caspase-5:329 nM (IC50) Caspase-11
In Vitro	Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts[1].
References	[1]. Jie Yang, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797.

Molecular Formula	C₂₆H₃₇ClN₄O₈
Molecular Weight	569.05

Hazard Codes	Xi