329182-61-8
329182-61-8 structure
- Name: JR-AB2-011
- Chemical Name: 3-(3,4-Dichlorophenyl)-1-(4-fluorophenyl)-1-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea
- CAS Number: 329182-61-8
- Molecular Formula: C17H14Cl2FN3OS
- Molecular Weight: 398.282
- Create Date: 2021-01-15 12:35:42
- Modify Date: 2024-02-27 19:27:49
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JR-AB2-011 is a potent and selective inhibitor of mTORC2 kinase activity. It markedly reduces mTORC2 signaling and IC50 while enhancing apoptotic levels in GBM cells.
| Name | 3-(3,4-Dichlorophenyl)-1-(4-fluorophenyl)-1-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea |
|---|---|
| Synonyms |
Urea, N'-(3,4-dichlorophenyl)-N-(4,5-dihydro-5-methyl-2-thiazolyl)-N-(4-fluorophenyl)-
3-(3,4-Dichlorophenyl)-1-(4-fluorophenyl)-1-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea N'-(3,4-dichlorophenyl)-N-(4-fluorophenyl)-N-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C17H14Cl2FN3OS |
| Molecular Weight | 398.282 |
| Exact Mass | 397.021881 |
| LogP | 4.89 |
| Index of Refraction | 1.660 |