1644158-57-5

1644158-57-5 structure

Name: ARN14974
Chemical Name: ARN14974
CAS Number: 1644158-57-5
Molecular Formula: C₂₄H₂₁FN₂O₃
Molecular Weight: 404.43
Catalog: Research Areas Cancer
Create Date: 2021-09-14 17:48:40
Modify Date: 2025-08-27 14:57:53
ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC50=79 nM)[1].

Name	ARN14974
Synonyms	3(2H)-Benzoxazolecarboxamide, 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)- MFCD32196894 ARN14974 6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide

Description	ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC50=79 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	ARN14974 (20 μM; 24 hours; SW403 and Raw 264.7 cells) inhibits acid ceramidase (AC) in a complex cellular environment, leading to the intended biochemical response, that is, increased ceramide and decreased sphingosine levels[1].
In Vivo	ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney[1]. ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively[1].
References	[1]. Pizzirani D, et al. Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase. Angew Chem Int Ed Engl. 2015;54(2):485-489.