ARN14974
Modify Date: 2025-08-27 14:57:53
ARN14974 structure
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Common Name | ARN14974 | ||
|---|---|---|---|---|
| CAS Number | 1644158-57-5 | Molecular Weight | 404.43 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H21FN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ARN14974ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC50=79 nM)[1]. |
| Name | ARN14974 |
|---|---|
| Synonym | More Synonyms |
| Description | ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC50=79 nM)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | ARN14974 (20 μM; 24 hours; SW403 and Raw 264.7 cells) inhibits acid ceramidase (AC) in a complex cellular environment, leading to the intended biochemical response, that is, increased ceramide and decreased sphingosine levels[1]. |
| In Vivo | ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney[1]. ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H21FN2O3 |
| Molecular Weight | 404.43 |
| Exact Mass | 404.153625 |
| LogP | 5.40 |
| Index of Refraction | 1.613 |
| 3(2H)-Benzoxazolecarboxamide, 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)- |
| MFCD32196894 |
| ARN14974 |
| 6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide |