873080-25-2
873080-25-2 structure
- Name: ZAP 180013
- Chemical Name: ZAP-180013
- CAS Number: 873080-25-2
- Molecular Formula: C19H17Cl2N3O4S
- Molecular Weight: 454.33
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Tyrosinase
- Create Date: 2020-08-08 12:33:43
- Modify Date: 2024-01-10 08:42:26
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ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1].
| Name | ZAP-180013 |
|---|
| Description | ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1]. |
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| Related Catalog | |
| Target |
IC50: 1.8 μM (ZAP-70)[1] |
| In Vitro | ZAP-70 is a critical molecule in the transduction of T cell antigen receptor signaling and the activation of T cells. Upon activation of the T cell antigen receptor, ZAP-70 is recruited to the intracellular ζ-chains of the T cell receptor, where ZAP-70 is activated and colocalized with its substrates. Inhibitors of ZAP-70 could potentially function as treatments for autoimmune diseases or organ transplantation. ZAP-180013 disrupts the interaction between ZAP-70 and the T cell antigen receptor. The IC50s in both FP and TR-FRET assays for ZAP-180013 are 9.6 μM and 16.841 μM, respectively[1]. |
| References |
| Molecular Formula | C19H17Cl2N3O4S |
|---|---|
| Molecular Weight | 454.33 |
| Hazard Codes | Xn |
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