2382719-60-8

2382719-60-8 structure
2382719-60-8 structure
  • Name: TT-OAD2
  • Chemical Name: TT-OAD2
  • CAS Number: 2382719-60-8
  • Molecular Formula: C50H49Cl4N3O6
  • Molecular Weight: 929.75
  • Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
  • Create Date: 2020-06-02 02:04:05
  • Modify Date: 2024-01-06 12:08:49
  • TT-OAD2 is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 has the potential for diabetes treatment[1][2].

Name TT-OAD2
Description TT-OAD2 is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 has the potential for diabetes treatment[1][2].
Related Catalog
Target

EC50: 5 nM (GLP-1 receptor)[2]

In Vitro TT-OAD2 (0-10 μM) inhibits GLP-1- and oxyntomodulin-mediated cAMP, calcium, pERK1/2 and β-arrestin responses in a concentration-dependent manner in HEK293A cells[1].
In Vivo TT-OAD2 (3 mg/kg; intravenous injection; male human GLP-1 receptor knock-in and knockout mice) treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice[1]. Animal Model: Male human GLP-1 receptor knock-in and knockout mice (6-11 months of age) with intravenous glucose tolerance tests[1] Dosage: 3 mg/kg Administration: Intravenous injection (Single dose) Result: Induced plasma insulin.
References

[1]. Zhao P, et al. Activation of the GLP-1 receptor by a non-peptidic agonist. Nature. 2020 Jan;577(7790):432-436.

[2]. Transtech Pharma, et al. Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof. WO2010114824A1.

Molecular Formula C50H49Cl4N3O6
Molecular Weight 929.75