1380006-72-3

1380006-72-3 structure

1380006-72-3 structure

Name: rel-((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate
Chemical Name: exo BCN-O-PNB
CAS Number: 1380006-72-3
Molecular Formula: C₁₇H₁₇NO₅
Molecular Weight: 315.32
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 11:35:43
Modify Date: 2025-08-25 13:19:45
exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	exo BCN-O-PNB
Synonyms	MFCD23378570

Description	exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₁₇H₁₇NO₅
Molecular Weight	315.32

Hazard Codes	Xi

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