Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DB07107
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Db07107
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

552332-71-5

552332-71-5 structure

552332-71-5 structure

Name: Db07107
Chemical Name: DB07107
CAS Number: 552332-71-5
Molecular Formula: C₂₃H₂₂N₄O
Molecular Weight: 370.45
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2020-06-01 14:31:22
Modify Date: 2024-01-10 16:11:49
DB07107 is a potent drug resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM[1][2].

Name	DB07107

Description	DB07107 is a potent drug resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Bcr-AblT315I Akt1:360 nM (IC50)
In Vitro	DB07107 is more effective in blocking drug-resistant T315I mutant than the wild-type Bcr-Abl. DB07107 (C23H22N4O) from DrugBank showed the highest binding energy with XP score of -14.045 kcal/mol[1].
References	[1]. Banavath HN, et al. Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study. Sci Rep. 2014 Nov 10;4:6948. [2]. Li Q, et al. Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1679-85.

Molecular Formula	C₂₃H₂₂N₄O
Molecular Weight	370.45

Hazard Codes	Xi