312928-72-6

312928-72-6 structure

Name: CRTh2 antagonist 3
Chemical Name: CRTh2 antagonist 3
CAS Number: 312928-72-6
Molecular Formula: C₁₉H₂₀N₂O₃S
Molecular Weight: 356.44
Catalog: Signaling Pathways PI3K/Akt/mTOR PDK-1
Create Date: 2020-04-11 11:33:10
Modify Date: 2025-08-25 10:25:24
CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist[1]. CRTh2 antagonist 3 (compound 4) also enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation[2].

Name	CRTh2 antagonist 3

Description	CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist[1]. CRTh2 antagonist 3 (compound 4) also enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation[2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1 Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology
Target	CRTh2[1] EC50: 2 μM (PDK1)[2] Ki: 8.4 μM (PDK1)[2]
References	[1]. Heinz Fretz, et al. 2-sulfanyl-benzoimidazol-1-yi-acetic acid derivatives as CRTH2 antagonists. US8273740. [2]. Rettenmaier TJ, et al. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. J Med Chem. 2015 Oct 22;58(20):8285-8291.

Molecular Formula	C₁₉H₂₀N₂O₃S
Molecular Weight	356.44