1357647-78-9

1357647-78-9 structure

Name: BRD-K98645985
Chemical Name: BRD-K98645985
CAS Number: 1357647-78-9
Molecular Formula: C₃₃H₄₃N₅O₄
Molecular Weight: 573.73
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2020-04-20 10:28:57
Modify Date: 2024-04-03 13:20:37
BRD-K98645985 is a class of 12-membered macrolactam and a BAF (Brg/Brahma-associated factors) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, and without T cell activation or toxicity[1].

Name	BRD-K98645985

Description	BRD-K98645985 is a class of 12-membered macrolactam and a BAF (Brg/Brahma-associated factors) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, and without T cell activation or toxicity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	BAF transcriptional repression:2.37 μM (EC50) HIV-1
In Vitro	BRD-K98645985 (30 µM; 18 hours) treatment shows a 5-fold increase in Bmi1, 2.6-fold increase in Ring1, and 3.3-fold decrease in Fgf4[1]. BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting[1].
References	[1]. Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.

Molecular Formula	C₃₃H₄₃N₅O₄
Molecular Weight	573.73