BRD-K98645985
Modify Date: 2024-04-03 13:20:37
BRD-K98645985 structure
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Common Name | BRD-K98645985 | ||
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| CAS Number | 1357647-78-9 | Molecular Weight | 573.73 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H43N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD-K98645985BRD-K98645985 is a class of 12-membered macrolactam and a BAF (Brg/Brahma-associated factors) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, and without T cell activation or toxicity[1]. |
| Name | BRD-K98645985 |
|---|
| Description | BRD-K98645985 is a class of 12-membered macrolactam and a BAF (Brg/Brahma-associated factors) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, and without T cell activation or toxicity[1]. |
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| Related Catalog | |
| Target |
BAF transcriptional repression:2.37 μM (EC50) HIV-1 |
| In Vitro | BRD-K98645985 (30 µM; 18 hours) treatment shows a 5-fold increase in Bmi1, 2.6-fold increase in Ring1, and 3.3-fold decrease in Fgf4[1]. BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting[1]. |
| References |
| Molecular Formula | C33H43N5O4 |
|---|---|
| Molecular Weight | 573.73 |