878983-38-1
878983-38-1 structure
- Name: AKOS-22
- Chemical Name: AKOS-22
- CAS Number: 878983-38-1
- Molecular Formula: C22H21ClF3N3O3
- Molecular Weight: 467.87
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-23 20:41:51
- Modify Date: 2025-08-25 23:47:16
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AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction[1].
| Name | AKOS-22 |
|---|
| Description | AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction[1]. |
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| Related Catalog | |
| Target |
Kd: 15.4 μM (VDAC1)[1] |
| In Vitro | AKOS-22 (5-20 μM; 2 hours) inhibits both VDAC1 oligomerization and apoptosis in a concentration-dependent manner (IC50=7.5 μM)[1]. AKOS-22 inhibits selenite-induced VDAC1 oligomerization, Cyto c release and apoptosis in HEK-293 cells (IC50=3.3-3.6 μM). AKOS-22 (30 μM, 2 h) inhibits cisplatin-induced VDAC1 oligomerization and apoptosis in neuroblastoma cell line SH-SY5Y. AKOS-22 prevents the elevation of [Ca2+]I associated with apoptosis induction, and thus Ca2+ accumulation by the mitochondria[1]. |
| References |
| Molecular Formula | C22H21ClF3N3O3 |
|---|---|
| Molecular Weight | 467.87 |