1400888-63-2

1400888-63-2 structure

Name: (2R,3R)-E1R
Chemical Name: (2R,3R)-E1R
CAS Number: 1400888-63-2
Molecular Formula: C₁₃H₁₆N₂O₂
Molecular Weight: 232.28
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2020-01-23 09:59:51
Modify Date: 2024-01-10 19:39:33
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

Name	(2R,3R)-E1R

Description	(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
In Vitro	Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer’s disease, major depressive disorders, and schizophrenia[1].
References	[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.