2241028-18-0
2241028-18-0 structure
- Name: miR-21 inhibitor 37
- Chemical Name: miR-21 inhibitor 37
- CAS Number: 2241028-18-0
- Molecular Formula: C21H17N7O3
- Molecular Weight: 415.413
- Create Date: 2020-01-12 08:56:03
- Modify Date: 2024-01-08 13:18:49
| Name | miR-21 inhibitor 37 |
|---|
| Description | |
|---|---|
| In Vitro | miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122; miR-21 inhibitor 37 has no effect on either mature or primary miR-21 levels in HeLa cells, as well as no effect on miR-21 transcription; exhibits low micromolar potency against different established cancer cells (MCF-7 and MIA PaCa-2, IC50=4.5 and 6.7 uM); shows significant rescue of both PDCD4 (9.5-fold increase) and PTEN (1.5-fold increase) levels inA498 RCC cells, sensitizes cells to topotecan-induced apoptosis. |
| Molecular Formula | C21H17N7O3 |
|---|---|
| Molecular Weight | 415.413 |