2554620-04-9

2554620-04-9 structure

Name: HIV-1 inhibitor-21
Chemical Name: HIV-1 inhibitor-21
CAS Number: 2554620-04-9
Molecular Formula: C₂₈H₂₄N₆O₂
Molecular Weight: 476.53
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-07-01 15:20:11
Modify Date: 2024-01-04 17:22:17
HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].

Name	HIV-1 inhibitor-21

Description	HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):12.7 nM (EC50) HIV-1 (K103N):10.4 nM (EC50)
References	[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874.

Molecular Formula	C₂₈H₂₄N₆O₂
Molecular Weight	476.53