902891-37-6
902891-37-6 structure
- Name: SHP 244
- Chemical Name: SHP 244
- CAS Number: 902891-37-6
- Molecular Formula: C23H17ClN4O3
- Molecular Weight: 432.864
- Create Date: 2020-01-20 10:22:56
- Modify Date: 2024-09-17 11:31:09
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SHP244 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 60 uM (SHP2 1-525), equipotent on the double mutant (SHP2T253M/Q257L IC50=68 uM), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
| Name | SHP 244 |
|---|
| Description | SHP244 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 60 uM (SHP2 1-525), equipotent on the double mutant (SHP2T253M/Q257L IC50=68 uM), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM). |
|---|---|
| References | References 1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C23H17ClN4O3 |
|---|---|
| Molecular Weight | 432.864 |