854165-96-1
854165-96-1 structure
- Name: RY796 racemate
- Chemical Name: RY796 racemate
- CAS Number: 854165-96-1
- Molecular Formula: C21H27N3O2
- Molecular Weight: 353.466
- Create Date: 2020-01-19 21:10:56
- Modify Date: 2024-04-11 19:40:52
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A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets.
| Name | RY796 racemate |
|---|
| Description | A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets. |
|---|---|
| References | References 1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64. 2. Li XN, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):407-16. View Related Products by Target Potassium Channel |
| Molecular Formula | C21H27N3O2 |
|---|---|
| Molecular Weight | 353.466 |