RY796 racemate
Modify Date: 2024-04-11 19:40:52
RY796 racemate structure
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Common Name | RY796 racemate | ||
|---|---|---|---|---|
| CAS Number | 854165-96-1 | Molecular Weight | 353.466 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H27N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RY796 racemateA novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets. |
| Name | RY796 racemate |
|---|
| Description | A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets. |
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| References | References 1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64. 2. Li XN, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):407-16. View Related Products by Target Potassium Channel |
| Molecular Formula | C21H27N3O2 |
|---|---|
| Molecular Weight | 353.466 |