688342-78-1
688342-78-1 structure
- Name: D-I03
- Chemical Name: D-I03
- CAS Number: 688342-78-1
- Molecular Formula: C23H36N6S
- Molecular Weight: 428.643
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-01-11 22:22:50
- Modify Date: 2024-04-08 12:02:09
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D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro; suppresses growth of BRCA1- and BRCA2-deficient cells (at 2.5 uM concentration) and inhibits RAD52-mediated SSA in human U2OS cells; selective toward SSA over homologous recombination (HR).
| Name | D-I03 |
|---|
| Description | D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro; suppresses growth of BRCA1- and BRCA2-deficient cells (at 2.5 uM concentration) and inhibits RAD52-mediated SSA in human U2OS cells; selective toward SSA over homologous recombination (HR). |
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| References | References 1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99. 2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. View Related Products by Target DNA Repair Protein |
| Molecular Formula | C23H36N6S |
|---|---|
| Molecular Weight | 428.643 |
| Hazard Codes | Xi |
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