618864-56-5
618864-56-5 structure
- Name: AF-399 42016530
- Chemical Name: AF-399 42016530
- CAS Number: 618864-56-5
- Molecular Formula: C26H17N3O4S3
- Molecular Weight: 531.619
- Create Date: 2020-01-20 16:57:56
- Modify Date: 2023-01-15 12:36:00
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A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo; enhances DC-mediated human CD4(+) T cell proliferation in an in vitro immune response model and amplifies cellular and humoral immune responses in vivo in experimental models, induces antigen-specific CD8+ T cells and tumor immunity against self antigens in combination with vaccines.
| Name | AF-399 42016530 |
|---|
| Description | A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo; enhances DC-mediated human CD4(+) T cell proliferation in an in vitro immune response model and amplifies cellular and humoral immune responses in vivo in experimental models, induces antigen-specific CD8+ T cells and tumor immunity against self antigens in combination with vaccines. |
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| References | References 1. Klein A, et al. Oncotarget. 2017 May 9;8(19):31079-31091. 2. Bayry J, et al. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6. 3. Pere H, et al. Blood. 2011 Nov 3;118(18):4853-62. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Molecular Formula | C26H17N3O4S3 |
|---|---|
| Molecular Weight | 531.619 |