1637300-25-4
1637300-25-4 structure
- Name: AF 64394
- Chemical Name: AF64394
- CAS Number: 1637300-25-4
- Molecular Formula: C21H20ClN5O
- Molecular Weight: 393.869
- Catalog: Research Areas Others
- Create Date: 2019-01-20 03:45:12
- Modify Date: 2024-01-05 08:36:18
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AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
| Name | AF64394 |
|---|---|
| Synonyms |
N-(4-Chloro-2-isopropoxybenzyl)-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, N-[[4-chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl- |
| Description | AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. |
|---|---|
| Related Catalog | |
| Target |
pIC50: 7.3 (GPR3)[1]. |
| In Vitro | AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H20ClN5O |
| Molecular Weight | 393.869 |
| Exact Mass | 393.135651 |
| LogP | 4.65 |
| Index of Refraction | 1.661 |
| Storage condition | 2-8℃ |