452967-14-5
452967-14-5 structure
- Name: IR415
- Chemical Name: IR415
- CAS Number: 452967-14-5
- Molecular Formula: C13H14F2N4S
- Molecular Weight: 296.34
- Catalog: Signaling Pathways Anti-infection HBV
- Create Date: 2020-01-11 19:10:50
- Modify Date: 2024-09-16 16:24:24
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IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease; exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells, selectively targets HBx in a concentration-dependent manner.
| Name | IR415 |
|---|---|
| Synonyms | MFCD00238878 |
| Description | IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease; exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells, selectively targets HBx in a concentration-dependent manner. |
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| References | References 1. Ghosh S, et al. J Biol Chem. 2017 Jul 28;292(30):12577-12588. View Related Products by Target HBV |
| Molecular Formula | C13H14F2N4S |
|---|---|
| Molecular Weight | 296.34 |
| Hazard Codes | Xi |
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