433954-52-0
433954-52-0 structure
- Name: Z-590
- Chemical Name: Z-590
- CAS Number: 433954-52-0
- Molecular Formula: C21H16N2O3S
- Molecular Weight: 376.43
- Create Date: 2020-01-19 21:52:55
- Modify Date: 2025-09-03 12:47:51
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Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity; significantly decreases the production of nitric oxide (NO), TNF-α, interleukin (IL)-6, IL-1β, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells; suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activatio in vivo.
| Name | Z-590 |
|---|
| Description | Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity; significantly decreases the production of nitric oxide (NO), TNF-α, interleukin (IL)-6, IL-1β, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells; suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activatio in vivo. |
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| References | References 1. Zhang Z, et al. Immunopharmacol Immunotoxicol. 2018 Apr;40(2):149-157. 2. Zhang Y, et al. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144. View Related Products by Target Other Targets |
| Molecular Formula | C21H16N2O3S |
|---|---|
| Molecular Weight | 376.43 |